Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

[Pikey]

College of Pharmacy, Oregon State University has done some interesting research

Link to National Library of Medicine -> https://pubmed.ncbi.nlm.nih.gov/35007072/

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants Richard B van Breemen 1, Ruth N Muchiri 1, Timothy A Bates 2, Jules B Weinstein 2, Hans C Leier 2, Scotland Farley 2, Fikadu G Tafesse 2 Affiliations expand PMID: 35007072 DOI: 10.1021/acs.jnatprod.1c00946 Abstract : As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.

 

[Kloud9]

Just having couple of bongs while reading

 

[Sedge]

Self vaxxing here too.

hey Ayeydized,,,,what do you reckon about that link ?
and are you a light or heavy smoker,,eater,,consumer,?

 

[nugget]

I was reading about this earlier and basically you need to use raw undecarbed plant material because it's cba and cbg (I think) that does the job they're talking about, smoking unfortunately doesn't help. Not gonna stop me from trying though

 

[Aye Shroomer]

Cool.
Light smoker here. Fill the vape up and that’s usually enough. Or maybe go a second time. It depends on what I need to do the next day really.

It was only a matter of time until a canna related study to rona came out. Good work.

Maybe the canna leaf juicing will be the go then

 

[Unknown User]

I wonder if you can stone the virus out of existence. Roll up one of those big ass colas. toke away.

 

[Billygoat]

Cool.
Light smoker here. Fill the vape up and that’s usually enough. Or maybe go a second time. It depends on what I need to do the next day really.

It was only a matter of time until a canna related study to rona came out. Good work.

Maybe the canna leaf juicing will be the go then

You had the rona yeah? How did it go?

 

[Billygoat]

I was reading about this earlier and basically you need to use raw undecarbed plant material because it's cba and cbg (I think) that does the job they're talking about, smoking unfortunately doesn't help. Not gonna stop me from trying though

sshhhhh. lol

 

[Old fox]

Just having couple of bongs while reading

Took me half ounce to read through all that Good message but. Must be true, my daughter ( still living at home) has been COvid positive last 2 days. Ive been toking heavily around her, and I feel great!

 

[Old fox]

I was reading about this earlier and basically you need to use raw undecarbed plant material because it's cba and cbg (I think) that does the job they're talking about, smoking unfortunately doesn't help. Not gonna stop me from trying though

That's the Aussie spirit. Sucking down bongs in the name of science

 

[RiverRat]

I was reading about this earlier and basically you need to use raw undecarbed plant material because it's cba and cbg (I think) that does the job they're talking about, smoking unfortunately doesn't help. Not gonna stop me from trying though

Will leaf do the trick?

 

[nugget]

Will leaf do the trick?

Honestly don't know maybe it'd be the same as butter etc more potent your starting product... Could (probably) be totally wrong though don't take my word for it at all lol

 

[RiverRat]

"To obtain high yields of CBGA, cannabis must be harvested in its earlier vegetative stage, before the compound converts into THC and CBD. Maximizing CBGA production means sacrificing THC and CBD levels. However, researchers have also recently uncovered a way to synthesize CBGA from yeast."

CBGA (cannabigerolic acid)

Cannabigerolic acid, or CBGA, is the raw form of CBG and is a unique compound that forms the building block for major cannabinoids THC, CBD, and CBC. Learn more about CBGA from Leafly.

www.leafly.com

Seems like they're both derived from leaf in the vegetative stage.

 

[Sedge]

cant remember what strain but I have seen one they said was high in CBG,,,,,,how different to CBGA ,,I has no ideas.

 

[Aye Shroomer]

You had the rona yeah? How did it go?

After a week I tested neg and went back to work. I didn’t feel too bad. Just sore and tired.
I had beer one night and wine another. Alcohol wouldn’t have helped but I did vape on one of the nights. Maybe that was the turning point and I got better after that